Open AccessThyroid stimulating hormone isn’t a sensitive indicator of iodine nutritional status in schoolchildren
Author(s) -
Renata de Oliveira Campos,
Joaquim Custódio Silva Júnior,
Elton Estrela Ramos
Publication year - 2016
Publication title -
revista de ciências médicas e biológicas
Language(s) - English
Resource type - Journals
eISSN - 2236-5222
pISSN - 1677-5090
DOI - 10.9771/cmbio.v14i3.14990
Subject(s) - medicine , iodine , thyroid , iodine deficiency , endocrinology , thyroglobulin , chemistry , organic chemistry
iodine deficiency disorders (IDD)are most common cause of preventable brain damage, mental retardation and stunted growth in children worldwide. Several indicators are complementary to urinary iodine concentration (UIC) for assessing iodine nutritional status, as thyroid size, thyroglobulin (Tg) and thyroid stimulating hormone (TSH) concentrations in the blood. Objective:analyze TSH in filter paper blood values and correlate with UIC in schoolchildren from public school at state of Bahia, Brazil . Methodology: cross-sectional study was conducted in 880 schoolchildren aged 6-14 years, randomly selected, of public schools in five cities of four micro-regions of Bahia between October 2013 and September 2014. TSH was analyzed in filter-paper blood and UIC were measured by adapted Sandell-Kolthoff reaction. Results: 880 blood samples on filter-paper were analyzed for TSH. The reference range previously established is 0.72 to 6.0 μ UI/mL . Results of this research TSH dosage ranged from 0.24 μ IU/L to 7.71 μ IU/L, with a mean of 1.01±0.55 μ UI/L and median 0.89 μ UI/L . Only one child presented TSH greater than 6.0 (7.71 μ IU/L); however, results of urinary iodine were consistent with a more than adequate nutrition iodine (243.70 μ g/L). There’ no correlation between TSH and UIC (r= 0.115; p= 0.002) .Conclusion: in the present study, schoolchildren showed low values of TSH, but the mean UIC was indicative of adequate iodine nutrition .