Open AccessCryptococcus neoformans – New Science for Discovering Melanin Modifiers
Author(s) -
R. Soundharya,
V Aruna,
G V Amruthavalli,
R Gayathri
Publication year - 2018
Publication title -
south asian journal of research in microbiology
Language(s) - English
Resource type - Journals
ISSN - 2582-1989
DOI - 10.9734/sajrm/2018/v2i329897
Subject(s) - cryptococcus neoformans , melanin , cryptococcus , organism , niacinamide , biology , microbiology and biotechnology , biochemistry , genetics , nicotinamide , enzyme
Aim: The present study was taken up to establish the effect of niacinamide on phenoloxidase lead melanogenesis and to prove the reliability of C. neoformans based screening methodology.
Methods: The organism was grown in the Minimal media in presence and absence of L- DOPA and Niacinamide and checked for its pigment producing ability at different time intervals.
Results: Niacinamide did not affect the pigmentation in Cryptococcus neoformans in the absence or presence of L-Dopa.
Conclusion: Cryptococcus neoformans as a biological tool for studying the mechanism of action of various melanin promoters/ inhibitors. The present study highlights the importance and usefulness of Cryptococcus neoformans based screening invention as it is cost effective rapid and ‘living cell model’.