Open AccessStructure Based Drug Discovery, Docking, Modelling, Synthesis and Anticancer Screening of Some Novel Quinoline Derivatives
Author(s) -
Bharat Shivaji Honde,
Kunkulol Rahul Rajendra
Publication year - 2022
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2022/v34i3a35384
Subject(s) - quinoline , docking (animal) , combinatorial chemistry , chemistry , cancer cell lines , human breast , stereochemistry , anticancer drug , drug discovery , mcf 7 , drug , pharmacology , cancer cell , organic chemistry , biochemistry , cancer , biology , medicine , nursing , genetics
A new series of (2-(substituted-phenyl) quinoline-4-yl) (3-(substituted phenyl)-5-phenyl-1H-pyrazol-1-yl) methanone derivatives was carried out docking modelling and synthesized. Purity was checked by TLC and chemical structures of synthesized compounds were elucidated by their IR, 1HNMR, MS analysis data. The synthesized compounds were screened for anticancer activity by using cell line MCF-7 (Human breast cancer cell line) correlate with docking modelling.