Open AccessAssessment of the Relation of Anti-TPO and TSH, T3 and T4 Levels between Some Subclinical Diabetes Patients in Iran
Author(s) -
Ebrahim Alinia-Ahandani,
Marwa Mohamed Adel Salama Matwalli,
Saheb Hosseinnejad,
Milad Sheydaei,
Hadi Darzi-Ramandi,
Zahra Alizadeh-Tarpoei,
Seyed Sara Heidary-Bazardehy
Publication year - 2022
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2022/v34i31a36081
Subject(s) - levothyroxine , subclinical infection , thyroid , medicine , endocrinology , thyroid peroxidase , anti thyroid autoantibodies , endocrine system , autoantibody , hormone , antibody , physiology , immunology
Background: As we know, around 28% of ills who had benign fibrocystic mastopathy mostly have shown antibodies of anti-TPO as well as around 80% of them that have shown the thyroid hypertrophy issue. The Assessment of thyroid peroxidase (TPO) as the main antigen agent of the thyroid microsomal fraction has enabled the progress of a sensitive and specific assay for the detection of the corresponding autoantibodies and other digestive fractions.
Aim: Effect of gender, climate, and age on the ATPO, TSH, T3 and T4 rates were assessed as a goal.
Materials and Methods: We evaluated the diagnostic validity of the anti-TPO, TSH, T3, and T4 assays and their relationships in 500 laboratory cases from Isfahan province with various types of thyroid and diabetes diseases and in controls. Age factor in the various levels of T3, T4, ATPO and TSH items is studied in the following research, which demonstrates a reduced rate in T4 factor of the 1st decade.
Results: In the present study, patients with high TSH levels had high TPO tests. Patients with high levels of ATPO usually had high TSH, and in patients with low thyroid status, high TSH and high ATPO, TSH levels were normalized with levothyroxine tablets. Those with a high ATP content and normal TSH levels may have hypothyroidism in the future.
Conclusion: We concluded that you should check the thyroid test every 6 months. This could be concluded from the following research that gender, age, race, and area all demonstrate some remarkable impacts on the levels of T4, T3, TSH, and ATPO.