Open AccessAntifungal Activity of Echinops echinatus and Fagonia cretica from Cholistan Desert-Pakistan
Author(s) -
Faheem Hadi,
Annum Khawer,
Amna Riaz,
Anaab Basharat,
Muhammad Habib-E-Ajmi,
Tahir Maqbool,
Muhammad Rafiq,
Muhammad Sarwar,
Muhammad Bilal Tahir,
Memoona Zahra
Publication year - 2022
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2022/v34i30a36062
Subject(s) - biology , aspergillus flavus , traditional medicine , agar , aspergillus niger , microbiology and biotechnology , fluconazole , aspergillus , antifungal , botany , medicine , bacteria , genetics
Background: Fungal infections are getting worse due to their resistance against available antibiotics and have always remain a problem. Homoeopathic mother tinctures are part of therapy in clinical patients with less side effects and much efficient against pathogenic infections.
Methodology: Echinops echinatus and Fagonia cretica plant mother tinctures were performed and used to evaluate the anti-fungal potential of these plants against potentially pathogenic fungal species like Candida albicans, Aspergillus ustus, Aspergillus niger and Aspergillus flavus by agar disc diffusion method. Three doses were used (0.25 ml, 0.5 ml and 1 ml volume per disc) and zone of inhibition was observed in millimetres and compared with positive control Fluconazole (2 mg/ml) which is commercially available.
Results: The results indicated efficacy of both mother tinctures showed remakarble activity against pathogens with zone of inhibition ranging 17.33 – 30.33 mm.
Conclusion: Current work indicated anti-infective potential of plants which can be added in therapy of infections in future after confirmation in in-vivo models.