Open AccessIn Situ Gel Drug Delivery System: A Review
Author(s) -
K. P. Dhanya,
C. Siji,
E. Jamshiya,
P. Nihal,
O. Deepthi
Publication year - 2022
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2022/v34i29b36056
Subject(s) - gellan gum , triacetin , in situ , drug delivery , lactide , polymer , materials science , solubility , lactic acid , pectin , plga , chemistry , chemical engineering , organic chemistry , nanotechnology , polymerization , nanoparticle , food science , biology , bacteria , engineering , genetics , biochemistry
In situ gel forming polymeric formulations are drug delivery systems that are in sol form before being administered to the body, but gel in situ from which the medication is released in a sustained and controlled manner. Temperature modulation, pH alteration, ions present in the site and ultraviolet irradiation are factors that influence gel formation. Gellan gum, alginicacid, xyloglucan, pectin, chitosan, poly (DL-lactic acid), poly (DL-lactide co glycolide), and poly caprolactone are some of the polymers used to make in situ gels. Solvents such as water, dimethyl sulphoxide, N-methyl pyrrolidone, triacetin, and 2-pyrrolidone are utilized for these formulations, depending on the solubility of the polymer. Major routes of administration of In situ gels are oral, ocular, rectal, vaginal, injectable, and intraperitonial. In comparison to conventional drug delivery systems, in situ gel forming polymeric formulations provide various advantages, including sustained and prolonged action. From a manufacturing standpoint, such devices are less complex to produce, resulting in cheaper investment and manufacturing costs.