Open AccessAntiulcer Activity and Isolation of Chemical Constituents from Ethanolic Stem Bark Extract of Ficus Bengalensis
Author(s) -
N. Anupama,
Jennifer Fernandes,
K. Adarsha Govinda
Publication year - 2022
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2022/v34i29a36043
Subject(s) - chemistry , phytochemical , traditional medicine , stigmasterol , petroleum ether , terpenoid , ficus , flavonoid , bark (sound) , quercetin , extraction (chemistry) , chromatography , botany , biology , organic chemistry , biochemistry , medicine , ecology , antioxidant
Aims: The screen the antiulcer activity and to isolate the phytoconstituents of stem bark extract of Ficus bengalgensis.
Methodology: The cleaned, dried and powdered stem barks of Ficus bengalgensis were subjected to extraction. The extracts were then packed into column chromatography for the isolation of phytoconstituents and they were characterized by IR, 1HNMR, 13CNMR and mass spectroscopy. Invivo antiulcer activity were performed by 4-H pylorus ligation and ethanol induced ulcer methods.
Results: Preliminary phytochemical studies showed the presence of steroids, terpenoids, flavonoids, carbohydrates. Isolation of extracts led to give compounds like triterpenoid, a steroid and a flavonoid. The extract was found to be safe up to 2000mg/kg body weight. Antiulcer activity was found significant at level P=05 when compared with control models in experimental animals.
Conclusion: From petroleum ether extract isolated alpha-amyrin acetate, stigmasterol and quercetin from chloroform extract. The presence of triterpenoids, steroids and flavonoid might be responsible for the antiulcer activity of the stem bark extract of Ficus bengalgensis.