Open AccessDesign, Synthesis of Mannich Bases Derivatives of Thiosemicarbazide and their Evaluation for Anticancer Activity using Potato Disk Bioassay Method
Author(s) -
Geetanjali Sandip Patil,
Sachin Ashok Pishawikar
Publication year - 2022
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2022/v34i27b36007
Subject(s) - mannich base , bioassay , chemistry , combinatorial chemistry , antifungal , antimycobacterial , pharmacology , organic chemistry , biology , microbiology and biotechnology , medicine , mycobacterium tuberculosis , tuberculosis , pathology , genetics
Mannich bases and thiosemicarbazide individually are known to show verity of pharmacological activities such as anti-inflammatory, anticancer, antifilarial, antibacterial, antifungal, anticonvulsant, anthelmintic, antitubercular, analgesic, anti-HIV, antimalarial, antipsychotic, antiviral and so forth. As novel attempt in present work in first step synthesis of verity of mannich bases is done using structurally different types of aldehyde, ketones and amines. The condensation of synthesized mannich bases is done with thiosemicarbazide to form a novel class of compounds called mannich bases of thiosemicarbazide. Use of bioassay is one of the ways of carrying out preliminary investigation of activity. A. tumefaciens induced potato disc tumor assay has been used to investigate anticancer activity of synthesized compounds. The compounds B2, B4, B25, B26, B28, B29 and B30 have shown same or better inhibitory activity compared to Gemcitabine used as standard.