Open AccessSynthesis, Characterisation and Evaluation of Azetidine-2-One Derivative
Author(s) -
S. Ramachandran,
S. Dheepika,
M. Deepak,
M. Duraiseelan,
B. S. Chandru,
M. Vijey Aanandhi
Publication year - 2022
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2022/v34i27a35992
Subject(s) - chloroacetyl chloride , azetidine , chemistry , derivative (finance) , antibacterial activity , antimicrobial , staphylococcus aureus , schiff base , amine gas treating , fourier transform infrared spectroscopy , escherichia coli , pyrimidine , nuclear chemistry , antifungal , spectroscopy , chloride , combinatorial chemistry , organic chemistry , stereochemistry , bacteria , microbiology and biotechnology , biochemistry , biology , physics , quantum mechanics , gene , financial economics , economics , genetics
Antibacterial, antifungal, anticancer, antitubercular, anti-HIV, analgesic, anti-inflammatory, and ulcerogenic activities have all been documented for azetidinone derivatives.
The reaction of Schiff base((Z)-N (4-dimethylamino)benzylidene)pyrimidine-2-amine) with chloroacetyl chloride yielded a novel chemical called Azetdine-2-one derivative. Fourier Transform Infrared Spectroscopy and Proton Nuclear Magnetic Resonance Spectroscopy were used to confirm the chemical structures of the produced substances. The antimicrobial activity shows that the compound showed mild Antibacterial activity against Staphylococcus aureus and Escherichia coli.