Open AccessAssociation of Inflammatory Markers with Metabolic Syndrome among Pre & Post-menopausal Women
Author(s) -
Khalida Shaikh,
Shabnam Aijaz Khowaja,
. Marvee,
Ghulam Nabi Pathan,
Bilal Razaque Memon,
Areeba Memon
Publication year - 2022
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2022/v34i23a35872
Subject(s) - medicine , metabolic syndrome , fibrinogen , body mass index , c reactive protein , outpatient clinic , obstetrics and gynaecology , cross sectional study , physiology , inflammation , obesity , pregnancy , pathology , biology , genetics
Background: Metabolic Syndrome (MetS) comprises of an array of clinical, physiological, metabolic and biochemical disturbances; associated with a systemic inflammatory response. The debilitating condition entails high morbidity and mortality and thus it is important to identify and resolve it timely; a goal which may be achieved with the help of biomarkers. Fibrinogen and hsCRP; highly sensitive C-reactive protein, are found to be increased in acute inflammations. The raised quantity is indicative of underlying inflammatory states and thus may be relevant to MetS.
Objectives: To determine the association of inflammatory markers with metabolic syndrome among pre & post-menopausal women.
Materials and Methods: This cross-sectional analysis was carried out on a sample of 278 women (aged at or above 25 years) presenting to the Outpatient Department of General Medicine and the Obstetrics – Gynecology at Liaquat University Hospital (Hyderabad) from 01-02-2020 to 01-10-2020. Data was collected using a structured interview-based proforma which include information about biodata and sociodemographic details of research participants and biochemical analysis (CRP, DLC and fibrinogen and insulin measurement).
Results: In this study a cumulative MetS prevalence was found out to be around 60% (63.7% as per IDF criteria and (57.6% as per ATP-III classifications). Women with MetS had higher levels of CRP and fibrinogen. Women with high fibrinogen levels and CRP suffered with more type of metabolic abnormalities.
Conclusion: The findings of this studies showed that with total body fat and fat percentage, body mass-index, have a positive association with the studied inflammatory markers (CRP and fibrinogen).