Open AccessUpdates in Diagnosis and Management of Ectopic Pregnancy
Author(s) -
Hesham Mohamed Hamad Morcy,
Luluah Maan Ramadan Abdullah,
Maryam Mohammed M. Alenezi,
Fai Sultan F. Almutairi,
Sama Abdulfattah M. Almadani,
Raghad Khalid R. Alruwaili
Publication year - 2022
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2022/v34i22b35860
Subject(s) - ectopic pregnancy , methotrexate , medicine , pregnancy , obstetrics , conceptus , abortion , folic acid , gynecology , fetus , biology , genetics
Ectopic pregnancy (EP) occurs when the conceptus becomes embedded and matures beyond the endometrial cavity, resulting in the foetus' mortality.
Ectopic pregnancy can become a lifethreatening issue if it is not diagnosed and treated promptly. The most common symptoms of an unruptured ectopic pregnancy are first-haemorrhage and abdominal pain.
Although these symptoms can also occur in intrauterine pregnancy and spontaneous abortion, when a pregnant woman shows them, clinicians should suspect ectopic pregnancy. Methotrexate, a folic acid antagonist, has been extensively studied in medicine. Methotrexate inhibits dihydrofolate reductase, causing trophoblastic cells to divide rapidly and reducing tetrahydrofolate levels (a cofactor for deoxyribonucleic acid and ribonucleic acid formation).