Open AccessLactate Dehydrogenase Enzyme Level in Women with Severe Preeclampsia: A Cross-sectional Study
Author(s) -
Nadia Hameed,
Yasmeen Bibi,
Shereen Memon,
Sanam Channa,
Muhammad Ali Memon,
Muhammad Nadeem Chohan
Publication year - 2022
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2022/v34i21b35845
Subject(s) - lactate dehydrogenase , preeclampsia , medicine , obstetrics , obstetrics and gynaecology , cross sectional study , gynecology , pregnancy , enzyme , pathology , chemistry , biochemistry , biology , genetics
Aim: To determine the frequency of raised lactate dehydrogenase enzyme in women with severe preeclampsia.
Study Design: Cross-sectional study.
Place and Duration: Obstetrics and Gynecology department at Liaquat University Hospital Hyderabad from June 2018 to December 2018.
Methodology: There were 141 primiparous women with severe preeclampsia, included in this study. After taking history regarding hypertension and obstetrical examination, patients were subjected to a relevant investigation that is, 5ml of blood sent to an institutional laboratory for the measurement of lactate dehydrogenase enzyme, if it is >400 U/L then it was labeled as raised.
Results: The frequency of raised lactate dehydrogenase enzyme (400 U/L) was 13.48% (19/141) women with severe preeclampsia.
Conclusion: About 14% of women having Pre-eclampsia had raised lactate dehydrogenase enzyme. Severe preeclampsia is associated with severe multisystemic involvement. Raised LDH levels are indicative of cellular damage and severe hypertension in pregnancy.