Open AccessA Comprehensive Review of a New Nanosuspension for Improving the Oral Bioavailability of Poorly Soluble Drugs
Author(s) -
G. Karthick,
D Akiladevi,
M. Irfan Ahamed
Publication year - 2022
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2022/v34i20b35828
Subject(s) - bioavailability , drug , drug delivery , solubility , pharmacology , absorption (acoustics) , medicine , chemistry , materials science , nanotechnology , organic chemistry , composite material
Nanosuspension is a novel drug formulation for the delivery of hydrophobic drugs. The problem of medications that are poorly water-soluble and have low bioavailability is countered by nanosuspension technology. Solubility is a significant physiochemical element that influences drug absorption and therapeutic effectiveness. Poor aqueous solubility has the potential to impair formulation development. Nanosuspension technology can improve the drug's stability and bioavailability. Nanosuspensions can be formulated for various routes of administration such as oral, parenteral, ocular, topical, and pulmonary routes. Nanosuspension can be used for targeted drug delivery also by mucoadhesive gels and ocular inserts. Recent studies were approached to develop nanosuspension on site-specific drug delivery.