Open AccessUse of Systemic Doxycycline as An Adjunct to Initial Periodontal Therapy in Mild to Moderate Generalized Periodontitis: A Randomized Clinical Trial
Author(s) -
Hakam Rabi,
Mohammad Assaf
Publication year - 2022
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2022/v34i16b35748
Subject(s) - doxycycline , medicine , periodontitis , randomized controlled trial , bleeding on probing , placebo , chronic periodontitis , adjunct , confidence interval , scaling and root planing , gingival and periodontal pocket , clinical trial , clinical attachment loss , dentistry , antibiotics , pathology , linguistics , philosophy , alternative medicine , microbiology and biotechnology , biology
Background: Antibiotics like doxycycline can show an anti-bacterial effect which can reduce the bacterial load and promote healing in patients with chronic periodontitis.
Aim: To evaluate the use of doxycycline as an adjunct to initial periodontal therapy in mild to moderate periodontitis.
Materials and Methods: Randomized controlled clinical trial was done on 24 patients. Plaque index score, bleeding on probing, periodontal pocket depth and attachment loss was evaluated at six-week and twelve-week intervals after treatment with systemic doxycycline along with deep scaling and placebo medication with deep scaling. Data obtained was analyzed using SPSS software version 22. T-test was used to compare results between the two groups.
Results: Independent T-test shows statistically significant reduction in plaque index score, bleeding on probing, periodontal pocket depth at six-week interval in doxycycline group as compared to the control group with deep scaling alone. There was a statistically significant gain in the attachment level at six-week interval in doxycycline group than initial periodontal therapy alone. This result was not statistically significant at the twelve-week interval.
Conclusion: The study shows doxycycline as a good adjunct to initial periodontal therapy; however, more studies are required to obtain strong evidence.