Open AccessRivaroxaban: Compatibilty with Pharmaceutical Excipients using DSC and FTIR Spectrophotometry
Author(s) -
Rama Rao Nadendla,
J. Satynarayana,
Jaya Krishna Burri
Publication year - 2022
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2022/v34i12a35554
Subject(s) - microcrystalline cellulose , differential scanning calorimetry , fourier transform infrared spectroscopy , magnesium stearate , rivaroxaban , croscarmellose sodium , chromatography , chemistry , materials science , nuclear chemistry , dosage form , cellulose , chemical engineering , organic chemistry , medicine , physics , warfarin , engineering , cardiology , thermodynamics , atrial fibrillation
Rivaroxaban (RN) is a recently developed potent oral anticoagulant. The aim of the present study envisages compatibility studies of rivaroxaban with crospovidone, sodium startch glycolate, magnesium stearate, talc, microcrystalline cellulose, aerosil, HPMC K100 M, croscarmellose sodium using Differential scanning calorimeter and FTIR spectrophotometer. DSC thermograms, of rivaroxaban and physical mixture of individual pharmaceutical excipient, exhibited the range of transition of the drug in between 224ºC and 232ºC. The FTIR graphs showed that the wave numbers of rivaroxaban, matched with all the chosen pharmaceutical excipients combinations. Thus the DSC and FTIR studies showed that RN was not interactive with selected pharmaceutical excipients and can be carried forward for further studies.