Open AccessSynthesis and Antimicrobial Activity of Schiff’s and N-Mannich Bases of Indoline 2, 3-Dione and Its Derivatives with N-(4-(4-Aminophenylsulphonyl) Phenyl) Acetamide
Author(s) -
Udit N. Soni,
Anoop Singh
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i64b36014
Subject(s) - acetamide , piperidine , indoline , chemistry , antimicrobial , mannich reaction , antibacterial activity , organic chemistry , formaldehyde , amine gas treating , proton nmr , nuclear chemistry , medicinal chemistry , bacteria , catalysis , biology , genetics
Indoline 2, 3-dione and substituted Indoline 2, 3-dione derivatives were reacted with N-(4-(4-aminophenylsulphonyl) phenyl) acetamide to generate a variety of Schiff's bases. Using these compounds' Mannich bases were created by reacting them with formaldehyde and secondary amine (piperidine). The compounds were all described using IR, 1H NMR spectroscopic data and elemental analysis. The antibacterial activity of the produced compounds was determined using the tube dilution and Well plate methods. When compound UNS-2 was incubated at concentrations of 100, 50, and 25mg/ml, it showed the greatest Zone of Inhibition against Enterococcus faecalis. When compared to the reference medication, all of the synthesised compounds demonstrated superior antimicrobial efficacy.