Protocol on Comparative Efficacy of Bruhatyadi Kwath as Compared to Furosemide for Improving e –GFR and Albuminuria in Chronic Kidney Disease-A Randomized Controlled Study

Background: The steady decrease of kidney function is referred to as chronic kidney disease. The kidney function is measured by Glomerular Filtration Rate (GFR). According to Ayurveda the CKD can be correlated to Mutraghatabecause of similarity of symptoms. In Ayurveda Mutraghata is described under Mutrarogawhich comes under Mutravahastrotas (urinary system). Objective: To assess and compare the efficacy of Bruhatyadikwath, Furosemide and Bruhatyadikwath along with Furosemide on symptoms, eGFR, and Albuminuria in various stages of Chronic Kidney Disease. Methodology: Total 90 patients will be divided in 3 equal groups. Patients in group A will be treated with Bruhatyadikwatha, group B patients will be treated with Furosemide and patients in group C will be treated with Bruhatyadikwatha and Furosemide for 90 days. Follow up will be taken after every 30 days. Expected Results: Furosemide along with Bruhatayadikwath will show better improvement in e-GFR and Albuminurea as compared to only treated with Bruhatyadikwath and Furosemide. Assessment of subjective criteria like edema, anorexia, weakness and vomiting will be done on day 0, 30, 60 and 90 whereas assessment of Serum creatinine, Blood Urea, Sr. Sodium, Sr. Potassium, eGFR (Cockcroft formula) and Albuminuria will be done before and after treatment (on 0 and 90th day). Result: Subjective and objective outcomes will be assessed by statistical analysis. Conclusion: It will be drawn from the result obtained.