Open AccessSynthesis, Characterization and Preliminary Biological Evaluation of New 3 and 4-nitro Isoindoline-1, 3-dione/phthalimide Analogues
Author(s) -
Sharad Sankhe,
Nitesh R. Chindarkar
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i631186
Subject(s) - isoindoline , phthalimide , chemistry , antifungal , phthalic anhydride , bioassay , combinatorial chemistry , antibacterial activity , nitro , in vitro , biological activity , stereochemistry , organic chemistry , bacteria , biochemistry , biology , microbiology and biotechnology , genetics , alkyl , catalysis
Aims: To synthesize new nitroisoindoline-1,3-diones analogues and evaluate their preliminary biological activities
Methodology: New isoindoline-1,3-diones analogues were synthesized by coupling phthalic anhydride derivatives with appropriate aromatic amines. Newly synthesized heterocyclic compounds were evaluated for their in vitro antibacterial activity against gram-positive bacterial strains and gram-negative bacterial strains. They were also tested for their in vitro antifungal activity against fungi strains. Determination of the preliminary antibacterial and antifungal activity were investigated using agar-dilution method. The structures of newly synthesized analogues were elucidated by 1H and 13C-NMR techniques.
Results: Bioassay indicated that some of the newly synthesized isoindoline-1,3-dione analogues shows moderate biological activities.
Conclusion: Newly synthesized analogues can be used as antibacterial or antifungal agents on modifications.