Open AccessAnticancer Potential from Rhizophora mucronata Plant Leaf Associated Streptomyces Species against the Breast Cancer Cell Line
Author(s) -
Akansha Kishen,
P. Sivaperumal,
R. Anitha,
Lakshmi Thangavelu
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i62b35628
Subject(s) - rhizophora mucronata , rhizophora , biology , streptomyces , botany , mangrove , rhizophoraceae , actinobacteria , mycelium , 16s ribosomal rna , bacteria , ecology , genetics
Rhizophora mucronata is small to a medium-sized evergreen tree growing to a height of about 20 to 25 meters (approximately 66 to 82 feet), on the banks of the river. These mangroves have anticancer, antioxidant, antifungal, and viral activities which enhance their existence. Streptomyces species are the largest genus of Actinobacteria. They are gram-positive and are found in soil, decaying vegetation, and mangrove leaves. The breast cancer cell lines are used to test the anticancer potential.
Aim: Aim of the study was to assess the antibacterial activity from Rhizophora mucronata, against breast cancer cell lines.
Materials and Methods: Rhizophora mucronata leaf samples were collected and Streptomyces sp was isolated from the mangrove leaf. Further, extraction metabolites from Streptomyces were done and an MTT assay was checked against the cancer cell line.
Results and Discussion: The Rhizophora mucronata associated Streptomyces sp was identified by colour of aerial mycelium, soluble pigments, and Spore chain morphology. Further, the secondary metabolites production was done. The potential anticancer activity from the Streptomyces metabolites was done.
Conclusion: Rhizophora mucronata mangrove plant leaf associated with Marine Streptomyces showed good anti-cancer activity. Further, an in-vivo study using the metabolites is possible in the future.