Open AccessComparative Evaluation of Salivary Interleukin-18 in Periodontitis Patients with or without Diabetes Mellitus
Author(s) -
B. Chithralekha,
M. Jeevitha,
Selvaraj Jayaraman
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i62a35162
Subject(s) - periodontitis , diabetes mellitus , medicine , gastroenterology , biomarker , chronic periodontitis , endocrinology , biochemistry , chemistry
Aim: The study was conducted to compare the salivary concentrations of interleukin-18 in periodontitis patients with or without diabetes mellitus
Materials and Methods: The sample size in the study was 30 and categorized into 3 groups, in each group 10 individuals were included in the respective category. The three groups are as follows: Group a- patients with clinically healthy gingiva, Group b- patients with periodontitis and diabetes mellitus, Group c- patients with periodontitis only.
Results: Salivary Interleukin-18 levels were found to be significantly higher (p<0.013) in periodontitis with diabetes mellitus (110±7.0 ng/L) when compared with periodontitis only (70.06±3.5 ng/L) and also when compared with healthy controls (66±5.6 ng/L).
Conclusion: From the study, diabetic patients with periodontitis have increased IL-18 levels than non-diabetic counterparts. Thus salivary IL-18 is an effective non-invasive biomarker associating periodontitis and diabetes mellitus.