Open AccessAnti-Inflammatory Effect of Three Novel Hydroxy Flavones
Author(s) -
Kumar Katragunta,
Reena Verma
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i61b35511
Subject(s) - flavones , cyclooxygenase , inflammation , pharmacology , proinflammatory cytokine , tumor necrosis factor alpha , chemistry , interleukin , flavonoid , in vitro , interleukin 6 , medicine , immunology , cytokine , biochemistry , enzyme , antioxidant , chromatography
Aim: The aim of the present study was to evaluate the anti-inflammatory effect of three 7-hydroxy flavone derivatives; 7-HF, 7,3’,4’-THF, and 7,8,3’-THF,
Materials and Methods: The acute anti-inflammatory effect of 7-hydroxy flavones was the effect of 7-hydroxy flavones on certain mediators of pain and inflammation like cyclooxygenases (COX-1 and COX-2), and pro-inflammatory cytokines (IL-1b and TNF- were investigated by using in vitro tests.
Results: The investigated 7hydroxy flavones produced a significant, the test compounds inhibited both the isoforms of cyclooxygenase, a higher degree of inhibition on COX-2 was evident. Concentration-dependent inhibition of other inflammatory cytokines like tumour necrosis factor-a and interleukin-1b was identified in the present study
Conclusion: conclusion of the present study reveal the pain and anti-inflammatory action of the investigated 7hydroxy flavones. The inhibitory effects of 7hydroxy flavone on various pro-inflammatory cytokines provide evidence for the mechanism of action of these compounds against pain and inflammation.