Open AccessAnti-Cancer Effect of Novel Hydroxy Flavons on Human Cancer Cell In vitro and In silico
Author(s) -
Kumar Katragunta,
Reena Verma
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i61b35501
Subject(s) - cancer cell lines , cancer , in silico , in vitro , cancer cell , mtt assay , cell culture , flavones , docking (animal) , chemistry , mcf 7 , cell , cancer research , biology , biochemistry , medicine , human breast , genetics , chromatography , nursing , gene
Anti-cancer effect of 7 hydroxy Favone and its derivatives were tested against human cancer cell lines such MCF-7 cell line using the in vitro by MTT assay in cancer cell lines. All the favones showed significant activity against all pathogens. 7-HF showed a maximum zone of inhibition against cancer cell lines. 7-try hydroxy flavones showed the lowest anti-cancer activity. And docking results shown as 7-HF has shown maximum docking -7.9, 7,8,3’-THF has -7.5 and 7,3’,4’ has -7.7. as per the results, 7 hydroxy flavone could be a possible source to obtain new and effective compounds to treat cancer.