Synthesis, Anti Cancer and Anti Fungal Studies of New Phenyl Ethylene Derivatives | Zendy

V. S. R. N. Phanikumar | Zendy; M. Kiranmai Reddy | Zendy; Ganapavarapu Veera Raghava Sharma | Zendy

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Synthesis, Anti Cancer and Anti Fungal Studies of New Phenyl Ethylene Derivatives

Author(s) -

V. S. R. N. Phanikumar,

M. Kiranmai Reddy,

Ganapavarapu Veera Raghava Sharma

Publication year - 2021

Publication title -

journal of pharmaceutical research international

Language(s) - English

Resource type - Journals

ISSN - 2456-9119

DOI - 10.9734/jpri/2021/v33i60b34801

Subject(s) - chemistry , ethylamine , dehydrohalogenation , ethylene , ethylene carbonate , potassium carbonate , acetone , dehydration , sulfonic acid , organic chemistry , nuclear chemistry , medicinal chemistry , catalysis , biochemistry , electrode , electrolyte

Synthesis of Phenyl ethylene derivatives (4a-4f ) are reported in this communication. Products were characterized by1HNMR, Carbon (13C) NMR and Mass spectral data. Synthesized compounds of 4a-4f were screened for anti cancer and anti fungal activities and their results are presented. The main intermediate (3) was prepared from 4-methoxy phenyl acetone (1) reacted with aqueous ethylamine and NaBH4 to get the compound (2).Further dehydrohalogenation of (2) with 4-bromobutanol and potassium carbonate at 80°C resultedin compound (3)which on further dehydration with p-toluene sulfonic acid under reflux conditionsgave 4a to 4f.

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