Open AccessA Rare Case of Adult Medulloblastoma Associated with Multiple Sclerosis: Case Report and Literature Review
Author(s) -
Assem S. Alrumeh,
Waleed A. Alkhalifah,
Abdulrahman Y. Alturki,
Zubair Syed,
Wafa Al Shakweer
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i59a34318
Subject(s) - medulloblastoma , synaptophysin , medicine , multiple sclerosis , radiation therapy , hydrocephalus , pathology , immunohistochemistry , radiology , psychiatry
Medulloblastomas are the most common primary malignant brain tumors in childhood. They are responsible for around 20–40% of all brain tumors in children. They rarely occur in adulthood, but here they only make up less than 1% of all brain tumors. The standard therapy consists of an operation in combination with radiation and chemotherapy, which are individually determined for the patient. In this article, we discuss a case of 47 years old female patient diagnosed with primary progressive multiple sclerosis since 1 year. After 3 months of the diagnosis, she deteriorated and became unable to walk. MRI showed a large patchy enhancing midline cerebellar mass with evolving hydrocephalus. Tumor expressed positive reaction with synaptophysin immunohistochemical stain rendering medulloblastoma diagnosis.