Open AccessRole of Surgical Intervention in Hereditary Spherocytosis with Haemolytic Anaemia, Splenomegaly and Jaundice
Author(s) -
K. Senthil Kumar,
K. Abinaya,
R. Anantharamakrishnan,
K. Pranay
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i57a33990
Subject(s) - hereditary spherocytosis , medicine , jaundice , spherocytosis , hemolytic anemia , anemia , pediatrics , gallstones , hemolysis , aplastic anemia , incidence (geometry) , gastroenterology , splenectomy , bone marrow , physics , spleen , optics
haemolytic anaemia, splenomegaly and jaundice, admitted in Chettinad hospital and research institute during one year period from January 2019 to January 2020. Surgical intervention is indicated for selected patients with hereditary spherocytosis with haemolytic anaemia and jaundice to abate the hemolytic process after correction of anaemia with blood transfusion. Pigmented gallstones are seen in more than 50% cases for which incidence increases with severity of hemolysis and with age. Complications include aplastic anemia (most common after parvovirus B19 infection), haemolytic crisis during inter-current infection, megaloblastic crisis – during folic acid deficiency, cardiomyopathy, hematological malignancies.