Open AccessTheophylline Derivatives' In-vivo Analgesic and Anti-Inflammatory Activities
Author(s) -
Faruk Alam,
Ruhul Amin,
Biplab Kumar Dey,
Josef Yakin,
Smriti Rekha Chanda Das,
Mohidul Islam,
Himangshu Deka,
Republica Borgohain,
Durgaprasad Kemisetti
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i57a33978
Subject(s) - theophylline , analgesic , chemistry , ammonium thiocyanate , in vivo , thiocyanate , chloride , aldehyde , pharmacology , medicinal chemistry , organic chemistry , medicine , catalysis , biology , microbiology and biotechnology
The reaction of theophylline and chloro-acetyl chloride produced an exceptional series of substituted theophylline derivatives (3A-3D), followed by ammonium thiocyanate and substituted aromatic aldehyde, and these synthesized derivatives were screened to study their analgesic and anti-inflammatory activities. UV, IR, H-1 NMR, mass spectral data, and CHN activities were used to describe the compounds, which were shown to be considerably efficacious at 100 mg/kg p.o., as well as experimental results that were statistically significant at the p <0.01 and p <0.05 levels.