Open AccessEtiology, Assessment and Management of WDHA (Watery Diarrhea, Hypokalemia, and Achlorhydria) and VIPoma
Author(s) -
Mohammed Salah Hussein,
RIdha A. Bdulmohsen Al Shaqaqiq,
Khaled Mubarak Aldhuaina,
Azhar Abdullah Al-qattan,
Salwah Mohammed Qaysi,
Abdulrahman Mubarak Almutairi,
Turki Bjad Bensgayan,
N Essa,
Fahad Mohammed Albaqami,
Fawaz Aldoohan,
Afnan Abdullah Obeed Aljohani,
Yousef Naif Alobaywi
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i56b33930
Subject(s) - hypokalemia , achlorhydria , medicine , gastroenterology , etiology , diarrhea , stomach
The syndrome of watery diarrhoea, hypokalemia, and achlorhydria (WDHA syndrome) is an uncommon disorder marked by severe, watery diarrhoea caused by non–beta pancreatic islet cell oversecretion of vasoactive intestinal peptide (VIP). The onset of the disease is gradual, and diagnosis is often months or years later. Long-term dehydration, electrolyte and acid-base abnormalities, and chronic renal failure are all linked to morbidity. Pancreatic endocrine tumours are extremely rare, with less than 10 incidences per million people. VIPomas are uncommon tumours that affect between 0.05 and 2.0 percent of people. The most prevalent symptom is diarrhoea, which affects at least 89 percent of patients. VIPoma is treated with a combination of medicine and surgery The goal of first medical treatment is to reduce symptoms and restore fluids and electrolytes as quickly as possible