Open AccessRole of Pentraxin-3 in Periodontal Inflammation - A Comprehensive Review
Author(s) -
Syed Wali Peeran,
Ahmed Elhassan,
Tazeen Dawood,
Karthikeyan Ramalingam,
Syed Ali Peeran,
Feryan Ahmed,
Abdul-Aziz Ahmed A. Adawi
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i55a33824
Subject(s) - ptx3 , inflammation , acute phase protein , medicine , c reactive protein , immunology , biomarker , biology , biochemistry
Acute phase reactants like C-reactive protein (CRP), and pentraxin 3 (PTX3) are increased with inflammation and tissue injury. PTX3 is an acute phase protein and a member of the long pentraxin family. CRP is synthesized in the liver but PTX3 is generated locally at the inflammatory site. It is a fluid-phase pattern-recognition molecule that regulates antimicrobial immunity and inflammation by interfering with selectin-dependent neutrophil recruitment and regulating the complement cascade. Hence, PTX3 could be used as a potential biomarker to identify inflammatory response in both acute and chronic diseases. In this review, we discuss the role of PTX3 in periodontal inflammation.