Role of Pentraxin-3 in Periodontal Inflammation - A Comprehensive Review | Zendy

Syed Wali Peeran | Zendy; Ahmed Elhassan | Zendy; Tazeen Dawood | Zendy; Karthikeyan Ramalingam | Zendy; Syed Ali Peeran | Zendy; Fatma Ahmed | Zendy; Abdul-Aziz Ahmed A. Adawi | Zendy

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Role of Pentraxin-3 in Periodontal Inflammation - A Comprehensive Review

Author(s) -

Syed Wali Peeran,

Ahmed Elhassan,

Tazeen Dawood,

Karthikeyan Ramalingam,

Syed Ali Peeran,

Fatma Ahmed,

Abdul-Aziz Ahmed A. Adawi

Publication year - 2021

Publication title -

journal of pharmaceutical research international

Language(s) - English

Resource type - Journals

ISSN - 2456-9119

DOI - 10.9734/jpri/2021/v33i55a33824

Subject(s) - ptx3 , inflammation , acute phase protein , medicine , c reactive protein , immunology , biomarker , biology , biochemistry

Acute phase reactants like C-reactive protein (CRP), and pentraxin 3 (PTX3) are increased with inflammation and tissue injury. PTX3 is an acute phase protein and a member of the long pentraxin family. CRP is synthesized in the liver but PTX3 is generated locally at the inflammatory site. It is a fluid-phase pattern-recognition molecule that regulates antimicrobial immunity and inflammation by interfering with selectin-dependent neutrophil recruitment and regulating the complement cascade. Hence, PTX3 could be used as a potential biomarker to identify inflammatory response in both acute and chronic diseases. In this review, we discuss the role of PTX3 in periodontal inflammation.

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