Open AccessAnti-inflammatory Activity of Herbal Tablet of Phyllanthus emblica on Carrageenan-induced Paw Edema in Wistar Rats
Author(s) -
Amulyaratna Behera,
Himansu Bhusan Samal,
Dinesh Kumar Sharma,
Satish Kanhar,
Atul Kadam,
Prachi Khamkar,
Suchismeeta Behera
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i54b33776
Subject(s) - carrageenan , phyllanthus emblica , friability , pharmacology , traditional medicine , edema , chemistry , medicine , drug , surgery , first pass effect
Aim: In the current investigation, tablet dosage form of hydroalcohol extract of leaves of P. emblica was developed and evaluated foranti-inflammatory activities.
Methodology: Hydroalcohol extract of leaves of P. Emblica (HPE) was prepared and formulated tablet dosage form. The mechanical properties e.g. hardness, friability, disintegration, and dissolution of tablet were evaluated. Anti-inflammatory activities of HPE (150 mg/kg) and HPE (650 mg) tablets were performed in carrageenan induced hind paw edema in wistar rats.
Results: The anti-inflammatory activity was found to be significant in carrageenan inducedpaw edema. HPE (150 mg/kg) and HPE tablets (650 mg) were significantly (p < 0.05) reduced the carrageenan induced paw edemaby 66.41% and 69.43% respectively as compared to carragenan control. The % inhibition of standard drug (dichlorofenac sodium) was recorded to be 70.18% after 5 h.
Conclusion: The study standardised the development of HPE tablet and its anti-inflammatory effect.