Open AccessEffect of Nigella sativa on Testosterone Level in Albino Rats Treated with Doxorubicin
Author(s) -
Ashok Kumar,
Sadia Sundus,
. Ata-ur-Rehman,
Sarwat Fatmee,
Muhammad Imran,
Safia Naz
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i51b33526
Subject(s) - nigella sativa , doxorubicin , testosterone (patch) , medicine , pharmacology , kidney , traditional medicine , physiology , chemotherapy
Objective: To measure the influence of Nigella sativa on testosterone level of albino rats treated with doxorubicin
Study Design: Investigational study.
Place of Study: Animal House, JPMC, Karachi,
Materials and Methods: This study was accompanied on 3-4 months old, 40 albino rats, in the animal house of BMSI, Anatomy department, Karachi for 5 weeks were taken for this study and distributed into 4 groups, A1, A2, A3 &A4. A1 served as control, A2 receive Doxorubicin 3 mg/kg /week intraperitonealy, A3 receive extract of Nigella sativa 1000mg/kg daily orally along with Doxorubicin 3 mg / kg /week intraperitonealy and A4 receive extract of Nigella sativa 1000mg/kg daily orally. At completion of study, animals were sacrifice and tissues were preserved for staining.
Time of Study: The time of study was 35 days.
Results: In A2 serum Testosterone was markedly decreased, i.e 3.093+0.091 ng/ml as compared to A1 though serum levels were extremely substantial raise in A3 when compared with A2. This shows amended role of Nigella sativa on Doxorubicin induced kidney.
Conclusion: This study reveals that Nigella sativa amended the serum levels of testosterone of doxorubicin induced kidney.