Open AccessClinical and Immunological Characteristics of Patients with Odontogenic Maxillary Sinusitis
Author(s) -
Artem Viktorovich Eldzharov,
Diana Arturoviazyan,
Ruslan Kazbekovich Esiev,
George Vladimirovich Toboev,
Jamilya Khuseinovna Uzdenova,
Zainab Magomednurovna Shabanova,
Zainutdin Abakarovich Abakarov,
Askerbiy Berslanovich Abrekov,
Adam Saidalvievich Babatkhanov,
Artem Evgenevich Mishvelov
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i50a33394
Subject(s) - medicine , sinusitis , etiology , exacerbation , odontogenic , sinus (botany) , disease , dentistry , paranasal sinuses , dermatology , surgery , pathology , immunology , botany , biology , genus
Inflammatory diseases of the maxillary sinus of odontogenic aetiology have a high prevalence and hold leading positions in the structure of otorhinolaryngological and dental morbidity. High-intensity lesions in all age and social groups, the lack of over the last decade a downward trend in frequency, refractory to traditional drug therapy determine the high medical and social problem significance.To date, the main treatment standard is the surgical removal of the “causal” infection focus, but this stage is not always resolved by complete recovery, in consequence of which the disease acquires a cyclical character. Many authors point out the role of the immune system in chronization of the inflammatory process in the sinuses and the development of exacerbation frequent periods. Treatment of odontogenic sinusitis is more complex and prone to relapses. The main objectives of treatment are differential diagnosis of odontogenic sinusitis and its treatment.In this regard, determination of the immunological reactivity state and search for pathogenetically significant disorders in the effector protective link in patients with odontogenic sinusitis becomes especially relevant. The article presents a detailed analysis of the immune status of 60 patients with odontogenic maxillary sinusitis caused by acute periodontitis, radicular cyst, and filling material. Clearly demonstated the results of the paranasal sinuses x-ray examination and clinical examination of patients. In the course of the research were found significant changes of immunological indicators for several considered criteria. They indicate the presence of pronounced autoimmune shifts in the subjects, which play a key role in aggravating the disease severity and its outcome. This type of research is crucial for the development of improved drug therapy strategies for individuals with odontogenic sinusitis aimed at correcting immune disorders. The aim of the article is research of the immunological molecular changes that occur in odontogenic sinusitis, and to lay the foundation for studying the molecular mechanism of odontogenic sinusitis.