Open AccessA Prospective Randomised Case Control Study on the Role of Probiotics in Controlling Chronic Kidney Disease Progression
Author(s) -
Aronkumar Reddy,
P. Dhana Lakshmi,
N. Hima Bindu,
R. E. Ugandar,
Y. Sai Vani
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i49a33329
Subject(s) - medicine , creatinine , kidney disease , uric acid , nephrology , prospective cohort study , renal function , gastroenterology , urology
Aim: To study the role of probiotics in controlling chronic kidney disease progression.
Sample: To correlate renal parameters like creatinine, urea, uric acid, PCR in patients with chronic kidney disease.
Study Design: It is a Prospective case control study
Place and Duration of the Study: Department of Nephrology, Santhiram Medical college and General Hospital, between December 2020 – May 2021.
Methodology: We included 150 patients with chronic kidney disease from in and out patient departments. In this study patients are divided into two groups; case and control group. Control group is treated with normal conventional therapy whereas the case group is treated with conventional therapy along with probiotics. The lab parameters like creatinine, PCR, urea, uric acid were analyzed before and after the therapy in both groups.
Results: The lab parameters were analyzed by paired student`s t- test and the p value of these parameters were found to be in control group creatinine ranges from (4.42+/- 2.84 to 3.54+/- 2.73) and in case/ interventional group creatinine ranges from (5.13+/-2.43 to 2.29+/-1.57) shows <0.001. It shows significant improvement in these parameters in both control and case group. CKD stages were analyzed by Chi- square test, the p value of CKD stages in case group was found to be <0.0001 and in control group it was found to be 0.03.
Conclusion: It shows that there is significant improvement is found in both interventional (case) and non-interventional (control) groups. But more betterment is observed in case group than in control group. Hence probiotics are used as a natural bio-treatment to control the progression of CKD and improves the quality of life.