Open AccessEvaluation of the Antigenotoxic Potential of Methanolic Leaves Extract of Triticum aestivum in Mice
Author(s) -
Gaurav Jain,
Shailesh M. Kewatker,
Govind Nayak,
Amit Nayak
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i47b33088
Subject(s) - mutagenesis , micronucleus , carcinogenesis , micronucleus test , biology , dna damage , reactive oxygen species , genotoxicity , dna , mutant , genetics , chemistry , cancer , gene , toxicity , organic chemistry
Mutations are changes to the nucleotide sequence of the genetic material of an organism. Reactive oxygen species (ROS) play an important role in process like mutagenesis, carcinogenesis and aging by their ability to damage cellular DNA. Inhibition of mutagenesis or carcinogenesis is generally not based on one specific mechanism. Protection against cancer can occur at different stages of the complicated processes of carcinogenesis. Naturally occurring antioxidants have been extensively studied for their capacity to protect organisms and cells from oxidation. Triticum aestivum (T. aestivum) have revealed its medicinal potential for some human diseases; therefore, this study aimed to evaluate the genotoxic and antigenotoxic potential of methanolic extract. To accomplish this, the methanolic extract of T. aestivum was evaluated for its antigenotoxic effect using the chromosomal aberrations and micronucleus assay of bone marrow cells of mice.T. aestivum extract has shown significant protection against Cyclophosphamide induced micronucleus formation and chromosomal aberrations.