Open AccessEvaluation of COX-2 Inhibitor Injurious Effects on Proximal Convoluted Tubular Diameter of Kidney with Favorable Impact of Lycopene in Albino Rats on the Basis of Microscopic Features
Author(s) -
Sadia Sundus,
Aisha Hassan,
Ashok Kumar,
Shah Jabeen,
Nadira Hameed,
Madiha Ajaz
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i47a33034
Subject(s) - lycopene , brush border , kidney , celecoxib , convoluted tubule , chemistry , apoptosis , medicine , endocrinology , zoology , biology , biochemistry , membrane , vesicle , carotenoid
Objective: To analyze the harmful effect of COX-2 inhibitor on proximal convoluted tubular diameter of kidney, amendment by lycopene.
Research Design: Experimental Research.
Abode of Research: Animal House, JPMC, Karachi.
Materials and Methods: 90-120 days old, forty healthy adult male Albino rats of 200-220gm weight were taken for this study and distributed into 4 cliques, set 1was chosen as control, in Set 2 Celecoxib was given 0.05g/1000g by gavage, in set 3 Celecoxib was given0.05g/1000g by gavage with lycopene 0.05g/1000g by gavage and set4 lycopene was given0.05g/1000g by gavage for 30 days. At accomplishment of study, animals were sacrifice and tissues were preserved for staining.
Results: Inset 2 proximal convoluted tubular diameter became distended due to apoptosis of lining epithelial cells. They turn into low cuboidal from simple cuboidal cells along with ill-defined brush border at the luminal surface due to scarce microvilli and had disrupted basement membrane, however renal structure were amended in set3 which were given celecoxib with lycopene.
Conclusion: This study reveals that lycopene amended the apoptotic changes of set2.