Open AccessReproductive Organ Activities of Morinda lucida Ethanol Root Extract on Male and Female Albino Rats Tramadol HCL Induced Infertility
Author(s) -
Nkiruka Millicent Amadi,
Peter Uwadiegwu Achukwu,
yelum V. Anoh,
Emmanuel Ifeanyi Obeagu,
Ngozika Obianuju Achukwu,
O. F. Odo
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i46b32942
Subject(s) - tramadol , infertility , epididymis , physiology , uterus , morinda , body weight , medicine , biology , andrology , traditional medicine , pregnancy , sperm , pharmacology , analgesic , genetics
Infertility is a serious issue disturbing reproductive ages in all society now and calling for solution for continuity. Infertility were induced on groups of animals with separate sexes; M, M1, M2 and M3; F, F1, F2 andF3 with daily subcutaneous administration of 20 mg/kg body weight tramadol HCl for 42 days before respective ethanol root extract administrations of (500, 1000, 1500) mg/ kg body weight for 10 days. The animals were anaesthetized and sacrificed; uterus, ovaries, testes, epididymis were dissected out for histomorphological studies. There is evidence of dose treatment of infertility among treated groups. From the organ weight study, both the male and the female organ weight in the groups remained significantly unchanged. There are dose dependent treatments with the male and female tramadol treatment. The result is more pronounced in the increased dose of ethanol root extract (1000 mg/kg and 1500 mg/ kg) body weight treated testicular cells. This study indicated that Morinda lucida has a prophylactic effect against tramadol-induced testicular damage.