Open AccessInfluence of Process Variables on Budesonide Nanoparticles Using Factorial Design
Author(s) -
Ashwin Kuchekar,
Jayesh Jathar,
Ashwini Gawade,
Bhanudas S. Kuchekar
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i431172
Subject(s) - dispersity , sonication , zeta potential , particle size , nanoparticle , factorial experiment , poloxamer , materials science , drug delivery , chemical engineering , budesonide , nanotechnology , scanning electron microscope , poloxamer 407 , chromatography , chemistry , mathematics , polymer chemistry , composite material , surgery , copolymer , polymer , medicine , corticosteroid , statistics , engineering
Aims: Nanoparticles are the colloidal carrier systems for delivery of poorly soluble drugs. Budesonide. (BUD) a corticosteroid practically insoluble in water is used in asthma treatment. The aim of the present research work was to develop and evaluate BUD nanoparticles.
Methodology: The prepared formulation was analyzed for % encapsulation efficiency, particle size analysis, zeta potential, polydispersity index (PDI), scanning electron microscopy and transmission electron microscopy. Poloxamer-188 was found in stabilizing BUD nanoparticles.
Results: The observed % encapsulation efficiency of the optimized batch was (82.95) %, particle size was 271.8 nm with PDI 0.456. Solvent injection method was successfully implemented to developed BUD nanoparticles poloxamer-188. Sonication time and amplitude played an important role in governing the particle size.
Conclusion: It can be inferred from the study that nanoparticles are a potential drug delivery method for poorly water-soluble drug delivery which can not only get impacted by formulation variables but also by process variables.