Open AccessHepatoprotective Potential of Tecomella undulata Bark on Paracetamol and CCL4 Induced Hepatotoxicity in Rats: Invitro Analysis
Author(s) -
Prasoon Kumar Saxena,
Deepak Nanda,
Ritu Gupta
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i42a32409
Subject(s) - hepatoprotection , alkaline phosphatase , bark (sound) , chemistry , malondialdehyde , glutathione , hepatotoxin , ethanol , pharmacology , carbon tetrachloride , ccl4 , traditional medicine , antioxidant , in vitro , dpph , enzyme , biochemistry , toxicity , biology , medicine , organic chemistry , ecology
In this study the T. undulata bark was tested for its hepatoprotection against paracetamol (PCM) induced hepatic damage and Carbon tetra chloride (CCl4) induced hepatotoxicity. The Invitro study was performed on HepG2 cell line .The Levels of serum marker enzymes i.e. AST, ALT (aminotransferases), ALP (alkaline phosphatase), GSH (reduced glutathione) and MDA (Malondialdehyde) in 70% Ethanol treated rats were monitored, respectively. The 70% Ethanol extract gave promising results as studied in detail. The Present study showed that the 70 % ethanolic extract of bark of T.undulata apparently revive the physiological integrity of hepatocytes. Thus the present study demonstrated the Hepatoprotective property of Tecomella undulate Bark.