Open AccessIn-vitro Anti-Cancer and Anti-Inflammatory Screening of Dodonaea viscosa
Author(s) -
Rajendiran Ramkumar,
Sureshkumar Periyasamy,
B. R. Venkatraman,
K. Sekar
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i39b32194
Subject(s) - hela , cytotoxicity , ic50 , in vitro , mtt assay , traditional medicine , malignancy , cell culture , potency , chemistry , medicine , pharmacology , biology , biochemistry , pathology , genetics
Background: The current investigation was done to assess the in vitro anticancer property of Dodonaea viscosa (D. viscosa) in three malignant growth cell lines and mitigating impact in RAW 264.7 macrophages.
Methods: The hydroalcoholic remove D. viscosa was ready and tried against HCT-116 colon malignancy, MCF-7 bosom disease HeLa cervical disease cell lines. The cytotoxicity of concentrate was affirmed by MTT cheeky. The calming movement of concentrate was assessed utilizing LPS invigorated RAW 264.7 macrophages and the degree of incendiary middle people was estimated.
Results: The anticancer impact of D. viscosa onHCT-116, MCF-7 and HeLa cell line with the IC50 worth of 60.43 ± 0.76 μg/ml,75.26 ± 0.45 μg/ml and 72.12 ± 0.87μg/ml individually. Further, in LPS stimulatedRAW264.7 macrophage cells, treatment with D. viscosa extract altogether decreased the raised level of NO, TNF-α and PGE2.
Conclusion: This examination gave the proof to D. viscosa an anticancer and mitigating specialist. Further bioactive confinement and atomic examinations are needed to prove the impact of plant remove.