Open AccessProtective Effect of Cucurbita maxima against Maximal Electroshock Induced Convulsions
Author(s) -
Nagnath R. Kadam,
P. Mohanty,
Ashish Jain
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i39a32146
Subject(s) - cucurbita maxima , maxima , phenytoin , anticonvulsant , chemistry , cucurbita , cucurbitaceae , pharmacology , medicine , epilepsy , biology , botany , biochemistry , art , psychiatry , performance art , art history
In the present investigation, an indigenous plant, Cucurbita maxima was studied for its protective effect against maximal electroshock (MES) induced convulsions in Wistar albino rats. The rats were pretreated with different doses (100, 200, 400 mg/kg) of hydroalcoholic extract of seeds of Cucurbita maxima for 14 days and then, they were subjected to maximal electroshock seizures (40 mA for 0.2 sec) treatment. Hydroalcoholic extract of Cucurbita maxima seeds at 200 and 400 mg/kg doses significantly reduced the duration of hind limb extension along with the protection of rats against maximal electroshock induced seizures. The reference standard i.e., phenytoin (20 mg/kg) provided complete protection. Thus, present study revealed anticonvulsant effect of Cucurbita maxima against maximal electroshock-induced convulsions in rats.