Open AccessPost COVID-19 Organizing Pneumonia: A Systematic Review and Meta-analysis
Author(s) -
Talal Khalid Alanazi,
Nasser Faris Ali Alahmari,
Faris Essa Ibrahim Qubays,
Solaiman Hosaian ibraheem Alenezi,
M Alenezi
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i38b32122
Subject(s) - covid-19 , pneumonia , meta analysis , web of science , observational study , medicine , systematic review , risk factor , medline , intensive care medicine , pathology , biology , disease , infectious disease (medical specialty) , biochemistry , outbreak
Several observational studies have found parallels between COVID-19 pneumonia and organizing pneumonia (OP). This study aims to investigate the published literature of OP related to COVID-19, estimates the prevalence of OP among COVID-19 patients, and assesses the risk or COVID-19 severity associated with OP.
Methodology: This was a systematic review and meta-analysis. A systematic electronic search through PubMed, Web of Science, Science Direct, EBSCO, and Google Scholar was conducted to include relevant and eligible literature. The authors used Review Manager 5.4 to perform quantitative data synthesis for the condition of interest analyses.
Results: A total of 9 eligible study articles and 12 case reports were included in this study. The estimated pooled organizing pneumonia prevalence among COVID-19 patients was 45.6% [23.1%-68.2%]. The association between OP and severe COVID-19 infection revealed a pooled OR [95% CI] of 5.22 [-0.96-11.41].
Conclusion: COVID-19 patients had a rather high OP prevalence (43%). Surprisingly, cancer patients with COVID-19 infection had the lowest OP prevalence. OP was identified as a possible risk factor for the severity of COVID-19 infection.