Open AccessMicrosponge: A Novel Tool for Topical Drug Delivery of Anti Rheumatoid Drugs
Author(s) -
Dipti Gohil,
Karishma Patel,
Kruti Indravadan Patel,
Shivani Tiwari,
Priyank Patel,
Nirmal Shah
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i37b31998
Subject(s) - drug , drug delivery , medicine , flexibility (engineering) , dosage form , route of administration , pharmacology , rheumatoid arthritis , nanotechnology , materials science , statistics , mathematics
Microsponge is developing field of technology which can achieve goal of site specific as well as controlled drug delivery. Physicochemical properties of microsponge like Particle size, particle size distribution, porosity, surface morphology plays a major role in selection of type of dosage form and route of administration for delivery of drug. Microsponge is also emerged as novel tool for delivering of drug by topical route. Topical route is having added advantage of formulation flexibility, greater patient compliance, improved safety and efficacy of formulation and aesthetic properties. Rheumatoid Arthritis is immunomodulatory disease which requires long term treatment for management of disease. Available oral formulation may cause liver toxicity upon long term use. Topical route can be suitable alternate route for delivery of drug with enhanced stability of drug, reduced side effects, and reduced frequency of administration. Due to porous and spongy structure of Microsponge, it has the capacity to entrap large amount of dose and can modify drug release too.