Open AccessAn Emerging Transdermal Drug Delivery System: Fabrication and Characterization of Natural and Biodegradable Polymeric Microneedles Transdermal Patch
Author(s) -
Deepesh Lall,
Mohd. Javed Naim,
Shruti Rathore
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i35b31897
Subject(s) - transdermal , materials science , stratum corneum , carboxymethyl cellulose , drug delivery , nanotechnology , biodegradable polymer , chitosan , biomedical engineering , polymer , chemical engineering , composite material , pharmacology , medicine , pathology , metallurgy , sodium , engineering
Promising drug agents are limited by their inability to reach in systematic circulation system when applied on skin, because of the excellent barrier of biological membranes, such as the stratum corneum (SC) of the skin. It is the outermost layer of the skin, SC, the principal barrier to all the topical application applied on skin. Various strategies were employed by many research group and pharmaceutical companies worldwide, for the formulation of microneedles. Therefore, microneedles (MN’s), used to puncture skin, it created the transient aqueous transport pathway and enhanced the trandermal permeability. Microneedles (MN’s) fabricated with natural and biodegradable polymer, such as carboxymethyl cellulose (CMC), and dextran. Inverse replication of micro milled master mould reproduced, solid out of natural polymeric microneedles, were subsequently assembled into transdermal patch and physiochemical characterized for dissolution index, mechanical strength constructed physical strong and uniform shape and size and inert profile. Although, dissolvable PVP and PVA based microneedle showed physical stability and MN’s, their different analyzed parameter is of promise for the fabrication matrix device of natural biodegradable polymeric microneedle transdermal drug delivery system.