Open AccessSynthesis, Insilico and Antibacterial Activity Studies of Substituted Dihydro-1, 2-Oxazole Benzopyran-2-One Hybrids
Author(s) -
Alphonsus D’souza,
Pankaj Kumar,
Abhishek Kumar,
M. Soundarya,
Prashant Nayak
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i35a31882
Subject(s) - oxazole , benzopyran , antibacterial activity , chemistry , dna gyrase , stereochemistry , antimicrobial , combinatorial chemistry , organic chemistry , escherichia coli , bacteria , biochemistry , biology , genetics , gene
A series of substituted dihydro-1, 2-oxazole benzopyran-2-one (SR1-SR6) were synthesized through the intermediate substituted benzopyran-2-one chalcones and were characterized using spectral analysis. Compounds were docked with receptor DNA Gyrase B (PDB code: 5L3J) to know its interaction and binding energy; ranges -3.38 to -2.15 kcal/mol. Further these compounds were tested for antibacterial activity using tube dilution method and MIC values were observed; ranges 3.12 to 25 µg/ml. Compound 3-(5-(m-tolyl)-4,5-dihydroisoxazol-3-yl)-2H-chromen-2-one (SR3) showed the best interaction with binding energy -3.38 kcal/mol and antimicrobial activity having MIC 3.12 µg/ml.
GRAPHICAL ABSTRACT