Synthesis, Insilico and Antibacterial Activity Studies of Substituted Dihydro-1, 2-Oxazole Benzopyran-2-One Hybrids | Zendy

Alphonsus D’souza | Zendy; Pankaj Kumar | Zendy; Abhishek Kumar | Zendy; M. Soundarya | Zendy; Prashant Nayak | Zendy

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Synthesis, Insilico and Antibacterial Activity Studies of Substituted Dihydro-1, 2-Oxazole Benzopyran-2-One Hybrids

Author(s) -

Alphonsus D’souza,

Pankaj Kumar,

Abhishek Kumar,

M. Soundarya,

Prashant Nayak

Publication year - 2021

Publication title -

journal of pharmaceutical research international

Language(s) - English

Resource type - Journals

ISSN - 2456-9119

DOI - 10.9734/jpri/2021/v33i35a31882

Subject(s) - oxazole , benzopyran , antibacterial activity , chemistry , dna gyrase , stereochemistry , antimicrobial , combinatorial chemistry , organic chemistry , escherichia coli , bacteria , biochemistry , biology , genetics , gene

A series of substituted dihydro-1, 2-oxazole benzopyran-2-one (SR1-SR6) were synthesized through the intermediate substituted benzopyran-2-one chalcones and were characterized using spectral analysis. Compounds were docked with receptor DNA Gyrase B (PDB code: 5L3J) to know its interaction and binding energy; ranges -3.38 to -2.15 kcal/mol. Further these compounds were tested for antibacterial activity using tube dilution method and MIC values were observed; ranges 3.12 to 25 µg/ml. Compound 3-(5-(m-tolyl)-4,5-dihydroisoxazol-3-yl)-2H-chromen-2-one (SR3) showed the best interaction with binding energy -3.38 kcal/mol and antimicrobial activity having MIC 3.12 µg/ml. GRAPHICAL ABSTRACT

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