Open AccessNatural Products in Drug Discovery: Approaches and Development
Author(s) -
P. S. Tresina,
Murugeswaran Santhiya Selvam,
A Rajesh,
A. Doss,
V. R. Mohan
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i35a31879
Subject(s) - drug discovery , natural product , drug , computational biology , pharmaceutical industry , isolation (microbiology) , drug development , biochemical engineering , risk analysis (engineering) , data science , microbiology and biotechnology , computer science , biology , business , engineering , pharmacology , bioinformatics , biochemistry
Historically, natural products (NP’s) have played a significant role in drug discovery, not only in cancer and infectious diseases, but also in other therapeutic areas including cardiovascular diseases and multiple sclerosis. Profit and loss, Partnerships and averages, natural products also present certain challenges for drug discovery, such as technical obstacles to screening, isolation, characterization and optimization, which added to decline in their search by the pharmaceutical industry from the 1990s onwards. In recent days the applications of molecular biological techniques have increased the availability of novel compounds that can be conveniently produced in bacteria or yeast or plant sources. In addition to this, combinational chemistry approaches are being based on natural product scaffolds to create screening libraries that closely resemble drug-like compounds. Employing these technologies gives us a chance to execute research in screening new molecules by means of a software and data base to ascertain natural products as a major source for drug discovery. It lastly directs to lead structure discovery. This review discusses plant based natural product drug discovery and how innovative technologies play a role in next generation drug discovery and highlights from the published literature on plants as sources of antiinflammatory agents.
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