Open AccessPrevalence of Urinary Tract Infection and Drug Resistance among Infants and Children in Pakistan
Author(s) -
Muhammad Sohail,
M Shahid,
Kumail Sajjad,
Muhammad Ayub,
Qasir Akram,
Sobia Alyas,
Yousma Javed,
Muhammad Asim Rana,
Qurban Ali,
MM Hafeez
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i33a31779
Subject(s) - amikacin , nitrofurantoin , ampicillin , medicine , ciprofloxacin , antibiotics , drug resistance , antibiotic resistance , klebsiella , antibiotic sensitivity , microbiology and biotechnology , biology , escherichia coli , biochemistry , gene
In infancy most common and a serious disease is known as Urinary tract infection (UTI). The aim of the current study is to evaluate the frequency and antibiotic resistant among infant presenting with UTI in Lahore General hospital, Lahore-Pakistan. The current observational study comprised 100 (n=100) cases diagnosed with UTI. The study was conducted at Lahore General Hospital, Pakistan, between March 2019 and January 2020. Data were collected and recorded on specified proformas that had information on demographics, biochemical analysis, and complaints, as well as the antibiotic used and blood cultures. The most common gram-negative bacilli (GNB) causing UTI was E. coli constitute about 72% followed by Klebsiella (11%), Enterobacter (7%) and Enterococcus (4%). Most of the isolated pathogens are highly resistant to ampicillin, cotrimoxazole, and cephalexin (72%–95%), have intermediate sensitivity to third- generation cephalosporins, and high sensitivity to amikacin, nitrofurantoin and ciprofloxacin. Similarly, the other pathogens showed different degree of occurrence and resistance against empirically used antibiotics. The most prevalent UTI causative organism among children was E. coli. The insulated microorganisms were highly resistant to ampicillin, and highly sensitive to amikacin.