Open AccessA Comprehensive Mini Review on Co-Crystallization Process
Author(s) -
Ananga Mohan Das,
Ruhul Amin,
Satyabrat Sarma,
Biplab Kumar Dey,
Faruk Alam
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i29a31580
Subject(s) - crystallization , crystal engineering , supramolecular chemistry , active ingredient , molecule , hydrogen bond , crystal (programming language) , chemistry , nanotechnology , crystal structure , crystal growth , materials science , combinatorial chemistry , crystallography , organic chemistry , computer science , bioinformatics , biology , programming language
Co‑crystal chemistry has recently attracted supramolecular scientists. Co-crystals are comprising of hydrogen bonding assembly between different molecules. Many issues related to the performance characteristics of an active pharmaceutical ingredient (API) can be resolved using the co-crystallization approach. A proper understanding of the crystal structure of an API is required for the successful formation of co-crystals with the selected co‑former. Co-crystal chemistry has recently attracted scientists from the super molecules. Co crystals consist of the assembly of hydrogen bonds between various molecules. Many problems related to the performance characteristics of an active pharmaceutical ingredient (API) can be solved using the method of co-crystallization. Co-Crystals offer an alternate pathway where any API, paying little mind to be acidic, essential, or ionizable gatherings, might be co-gem. This aspect also helps to complement existing methods by reintroducing molecules with limited pharmaceutical profiles based on their non-ionizable functional groups.