Evaluation of Hemidesmus indicus Plant Compounds for Anti-Cancer Studies – An In silico Approach | Zendy

Pavan Kumar Tummala | Zendy; Sreeja Nannapaneni | Zendy; Sumana Pratyusha Durvasula | Zendy; C. Supriya | Zendy; Sunandini Venigandla | Zendy; Srikanth Vemuru | Zendy; Suryanarayana Veeravilli | Zendy; Maheswara Reddy Mallu | Zendy

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Evaluation of Hemidesmus indicus Plant Compounds for Anti-Cancer Studies – An In silico Approach

Author(s) -

Pavan Kumar Tummala,

Sreeja Nannapaneni,

Sumana Pratyusha Durvasula,

C. Supriya,

Sunandini Venigandla,

Srikanth Vemuru,

Suryanarayana Veeravilli,

Maheswara Reddy Mallu

Publication year - 2021

Publication title -

journal of pharmaceutical research international

Language(s) - English

Resource type - Journals

ISSN - 2456-9119

DOI - 10.9734/jpri/2021/v33i26a31472

Subject(s) - in silico , traditional medicine , medicinal plants , chemistry , medicine , biochemistry , gene

Background: Phytocompounds in medicinal plants have a wide range of properties and are alternative medicines for those who cannot be helped by conventional medicine. Objective: In this work we have selected bioactive compounds from Hemidesmus indicus medicinal plant extracts. Methods: Gas chromatography and Mass spectrum studies were studied to identify the compounds present in the ethanolic extracts based on the retention time and area. Results: The identified compounds were used for anti-cancer activity by insilico method with BCL-2 which plays prominent role in causing cancer. Conclusion: Out of twenty selected compounds, docking results showedMethyl-1-Cyclohexane carboxylate and 1,2-diacetoxy-5-idohexane as best docked to the BCL-2.

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