Open AccessEvaluation of Hemidesmus indicus Plant Compounds for Anti-Cancer Studies – An In silico Approach
Author(s) -
Pavan Kumar Tummala,
Sreeja Nannapaneni,
Sumana Pratyusha Durvasula,
Supriya Chadalavada,
Sunandini Venigandla,
Srikanth Vemuru,
Suryanarayana Veeravilli,
Maheswara Reddy Mallu
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i26a31472
Subject(s) - in silico , traditional medicine , medicinal plants , chemistry , medicine , biochemistry , gene
Background: Phytocompounds in medicinal plants have a wide range of properties and are alternative medicines for those who cannot be helped by conventional medicine.
Objective: In this work we have selected bioactive compounds from Hemidesmus indicus medicinal plant extracts.
Methods: Gas chromatography and Mass spectrum studies were studied to identify the compounds present in the ethanolic extracts based on the retention time and area.
Results: The identified compounds were used for anti-cancer activity by insilico method with BCL-2 which plays prominent role in causing cancer.
Conclusion: Out of twenty selected compounds, docking results showedMethyl-1-Cyclohexane carboxylate and 1,2-diacetoxy-5-idohexane as best docked to the BCL-2.