Open AccessSynthesis and Antimicrobial Activity of Some New Coumarin Incorporated Pyridine-3-carbonitrile Derivatives
Author(s) -
Abhishek Kumar,
Pankaj Kumar,
Prashant Nayak,
D S Sandeep,
Sneh Priya,
Jainey P. James,
H. Shravya
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i21a31364
Subject(s) - malononitrile , ammonium acetate , antimicrobial , knoevenagel condensation , ethyl acetoacetate , salicylaldehyde , chemistry , coumarin , piperidine , rabeprazole , organic chemistry , benzaldehyde , combinatorial chemistry , catalysis , stereochemistry , biochemistry , schiff base , proton pump inhibitor , high performance liquid chromatography
Drug resistance causes serious difficulties in the routine therapy for curing common microbial infections. Thus it is very essential to develop new antimicrobial agents which can offer alternative treatments. The development of potent and effective antimicrobial agents is of utmost importance to overcome the emerging multidrug resistance strains of bacteria and fungi. The technique involves Knoevenagel reaction between substituted salicylaldehyde and ethyl acetoacetate in presence of piperidine as catalyst to give 3-acetyl coumarin. The intermediate coumarinyl chalcones was synthesized by condensing with various substituted benzaldehyde in presence of ethanolic KOH. The final synthesized pyridine-3-carbonitrile derivative was prepared upon refluxing with coumarinyl chalcones with malononitrile in presence of ammonium acetate. All the newly synthesized compounds were assigned on the basis of IR, 1H NMR and mass spectral data. The finalsynthesized compounds were screened for their antibacterial activity tube dilution method. Most of the compounds showed promising MIC by tube dilution method as compared to standard Cephalosporin.