Open AccessSynthesis, Characterization and Evaluation of Anti-tubercular Activity of Ofloxacin Chalcone Conjugates
Author(s) -
Ramakrishna Chintakunta,
Venkata Subbareddy Gopireddy
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i1631292
Subject(s) - ofloxacin , chalcone , chemistry , streptomycin , pyrazinamide , nuclear chemistry , ciprofloxacin , solvent , chromatography , mycobacterium tuberculosis , combinatorial chemistry , stereochemistry , organic chemistry , tuberculosis , biochemistry , antibiotics , medicine , rifampicin , pathology
Synthesis and characterization of Ofloxacin Chalcone derivatives were carried out and evaluated for their antitubercular activity. Synthesized Ofloxacin Chalcone derivatives (Compound A to F). These molecules are characterized by analytical methods (TLC), melting point, and Spectroscopic methods (FT-IR, Mass, NMR). The evaluated antitubercular activity of molecules of synthesized compounds and Ciprofloxacin Pyrazinamide, and Streptomycin as standard drugs. concentrations of synthesized derivatives were prepared (0.8, 1.6, 3.12, 6.25, 12.5, 25, 50, 100 µg/ml) by using sterile deionized water as a solvent. Antitubercular Assay was Performed by Mycobacterium tuberculosis using the MABA method. Analyzed MIC values. Compound E showed the best results among 6 Compounds at a very low concentration at 3.12 µg/ml.