Open AccessStudy of the Influence of Local Strains of Lactobacillus on the Experimental Model of Ulcerative Colitis
Author(s) -
Guzal Jumaniyazo Kutlieva,
N. A. Elova,
Bakhora Ismoilovna Turaeva,
D. K. Nurmukhamedova,
B. S. Tulaganov
Publication year - 2021
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2021/v33i1631290
Subject(s) - probiotic , ulcerative colitis , bacteria , lactobacillus , lactic acid , colitis , in vivo , microbiology and biotechnology , antimicrobial , biology , medicine , immunology , pathology , disease , genetics
The article is devoted to one of the most important effects of local strains of lactic acid bacteria - the detection of anti-inflammatory action. For this purpose, studies were conducted on an experimental model of ulcerative colitis caused in experimental animals (mice). The data proving that the effect of various probiotic bacteria is unequal are presented. The ability of probiotic lactic acid bacteria in vitro and in vivo systems to influence the production of pro - and anti-inflammatory cytokines, to stimulate antimicrobial, anti-inflammatory, and protective effects have been shown. It is shown that it is necessary to study the specific effect of local lactobacillus strains on anti-inflammatory properties for a more adequate, effective selection of probiotic drugs in the treatment of intestinal ulcers. Data have been presented proving the positive effects of probiotic bacteria on the wound key.